When faced with devastating events nature responds with unsentimental positivity and spontaneous creativity—this is the primary Biophilic lesson that must permeate our approach as we tackle COVID-19’s nearly existential threat to the built environment. Biophilic design can help take these and many more positive lessons from nature to rearrange how buildings are organized and accessed while also making them more compelling and inviting spaces that foster connections while maintaining separation, bring in light while defining boundaries, and have moments of intangible joy and discovery for their occupants.